PE-22-28
PE-22-28 is a synthetic peptide fragment derived from the pro-neurotrophin domain, researched for its potential neuroprotective and cognitive-enhancing properties in preclinical models.
- Category
- Neuroprotective / Cognitive Peptides
- Purity
- 98%
- Price
- from $275.00
- Availability
- In stock
- Size
- 10mg
- CAS number
- 11116-36-8
- Molecular formula
- C₆₄H₉₆N₂₀O₁₉ (MW: 1473.54 g/mol)
- Storage
- Store lyophilized powder at -20°C in a dry, light-protected environment. After reconstitution, store at 2–8°C and use within 14 days. Avoid repeated freeze-thaw cycles.
- Half-life
- Approximately 2–4 hours in vivo (estimated)
About PE-22-28
PE-22-28 is a synthetic heptapeptide derived from the pro-domain of brain-derived neurotrophic factor (proBDNF). It has been studied for its ability to modulate neurotrophin signaling pathways, particularly by interacting with the p75 neurotrophin receptor (p75NTR) and sortilin. Research suggests that PE-22-28 may play a role in regulating neuronal survival, synaptic plasticity, and cognitive function.
In preclinical studies, PE-22-28 has demonstrated potential anxiolytic and antidepressant-like effects, along with improvements in memory and learning tasks. Its mechanism of action involves the inhibition of proBDNF-p75NTR-sortilin signaling, which is associated with neuronal apoptosis and synaptic retraction when overactivated.
Store in a cool, dry environment: Store lyophilized powder at -20°C. After reconstitution, refrigerate at 2–8°C.
Related Nootropic & Cognitive Peptides
PE-22-28 Certificate of Analysis · All research peptides
For laboratory research use only. Not for human consumption.